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and D.J.) and RP230072 (to B.G.), and the Olga Keith and Harry Carothers Wiess Distinguished University Chair in Cancer Research Endowment Fund (to A.C.K.), as well as National Institutes of Health grants R01CA181196, R01CA244144, R01CA247992, R01CA269646 (to B.G.) and U54CA274220 (to B.G