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10.1001/jamanetworkopen.2019.9687 82 ReisN.SchwartzO.MilitianuD.RamonY.LevinD.NormanD.et al (2003)

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In circadian biology, DUBs serve as key modulators of clock protein stability, ensuring the robustness and proper timing of transcriptional-translational feedback loops that drive 24-h rhythms (Harris-Gauthier et al., 2022)

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The specific SNP ( rs28674628 ) is located in a predicted binding site for the miRNA miR-515-5p, which directly regulates IGF-1R levels, in the 3 UTR of the IGF-1R gene as demonstrated by computational analysis