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Homocysteine and lipids: S-Adenosyl methionine as a key intermediate
Tumor cells show glutamine addiction, and its deficiency often arrests cancer cells in the S phase (54)
Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]
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