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The absence of growth hormone-related side effects, no impact on glucose metabolism or IGF-1, and favorable comparison to other fat loss interventions make it a valuable option for appropriate individuals

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doi:10.1155/2011/297315

a recent safety analysis found no anaphylaxis in hundreds of patients receiving high-dose IV thiamine, suggesting the risk is very low in practice

However, when combined with insulin or sulfonylureas, the risk of hypoglycemia increases substantially, potentially affecting twenty to thirty percent of patients if doses of concurrent medications are not appropriately adjusted