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AGEs impair the BDNF-TrkB pathway, thereby impairing neuroplasticity, and cause endothelial dysfunction by forming cross-links in the arterial wall and collagen, leading to stiffness and impaired brain microcirculation (8)

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Giesbertz P, Ecker J, Haag A, Spanier B, Daniel H

Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease and cancer: US Preventive Services Task Force recommendation statement

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