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Glucagon secretion increases quickly following food intake and is directed primarily to the liver in order to stimulate hepatic glycogenolysis during meals [78]

In another study that examined the role of exenatide in improving coronary endothelial function in newly diagnosed type 2 diabetic patients in a randomized controlled trial, the coronary endothelial function was assessed by measuring the coronary flow velocity reserve (CFVR) which was improved significantly after 12 weeks of treatment with exenatide, CFVR was correlated inversely with hemoglobin A1c (Hb A1c) and positively with high-density lipoprotein cholesterol (HDL-C), this was also associated with a decrease in serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) was remarkably decreased in the exenatide treatment group compared with the baseline and the control group emphasizing the anti- inflammatory effects of exenatide

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