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Several xenobiotics induce PPAR activity, resulting in liver enlargement by stimulating the proliferation of hepatocyte peroxisomes and inducing the fatty acid oxidation enzyme CYP4A in rats and mice (Bentley et al

In conclusion, the temporal proteomic profiling performed in this study defines a clear developmental roadmap for liver organoids, offering actionable insights for optimizing their use in drug metabolism, toxicological testing, and disease modeling