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Within-cell analyses in human-GLP1R-expressing neurons confirmed depolarization from baseline and a reduced time to spike threshold during current injection, indicating increased excitability following danuglipron application (Extended Data Fig

This process is designed to mimic the natural creation of theanine in tea leaves, starting with the same compounds converted to theanine within the plant: ethylamine and L-glutamine

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These are consistent with the class of compounds it belongs to and often lessen over time