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Semaglutide works by mimicking GLP-1 (glucagon-like peptide-1), a hormone that tells your brain youre full and slows down how quickly food leaves your stomach

McDonald ES et al

There's also an extended-release formula that breaks down more slowly

The threshold at which tirzepatide meaningfully reduces food intake rises as your body acclimates

Imaging measures of MASLD, such as ultrasound, are less sensitive, specific, and reproducible than noncontrast MRI and liver biopsy at detecting mild steatosis, though their use is more feasible for pregnant patients (16)

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