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Additional miRNAs, including miR-135b (186,187), miR-20a (188), miR-92a and miR-144* (189), can be detected in the faecal matter and may serve as useful biomarkers for the screening and diagnosis of CRC
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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]
Increasing research shows that different gut bacteria participate in the synthesis of these toxins