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The engineered drug localized to lipid-rich plaque regions and CD11b/CD11c inflammatory cells, effectively suppressing inflammatory responses and enhancing cholesterol efflux ( By promoting cholesterol efflux and reducing foam-cell content within plaques, GLP-1RA therapy may decrease lipid core size and necrotic burden, thereby stabilizing the fibrous cap, lowering the risk of plaque rupture, and potentially reducing acute coronary events

This approach represents a fundamental shift from the conventional more is better mentality in medicine

Abstract Background and Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for type 2 diabetes mellitus (T2DM) and obesity

J.et al

Not perfect