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OPG deficiency increases the number of M cells in gut-associated lymphoid tissue (GALT), enhances antibody responses to commensal bacteria, alleviates IBD, and reduces inflammation-induced abnormalities in bone metabolism (235)

And thats the nuance right? Nutter says

Medical management may include the use of antacids, H2 receptor antagonists, or proton pump inhibitors (PPIs), depending on the severity of the symptoms and the individual patients health profile

Severe gastrointestinal problems: I try to avoid GLP-1s, including Zepbound and Wegovy, if a patient has chronic pancreatitis or severe gastroparesisslow gastric emptying usually caused by diabetes, Dr

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