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NAD + /NADH ratios reflect redox status and play an integral part in the ETC, with NADH being the primary electron donor

For instance, certain polymorphisms in COL1A1 are associated with a reduced ability to produce strong, well-organized collagen fibers, making the ligament less capable of withstanding mechanical stress

doi:10.1124/jpet.108.149211 Raun K, Hansen BS, Johansen NL, et al