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Furthermore, the first three eigenvectors were collected from each MD simulation trajectory and plotted to demonstrate the residual displacement in the different conformations of the protein structure, where a gradient color change (from blue to white to red) specifies that there are regular leaps among the various conformation of protein structure throughout the trajectory (Fig

Specifically, activation of Gs by LPARs stimulates adenylyl cyclase and increases cyclic AMP (cAMP) levels