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[DOI] [PMC free article] [PubMed] [Google Scholar] Gonzalez-Guerrero M

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Activation of NF-B pathway signaling initiates the transcriptional release of IL-6, TNF-, etc., and promotes the polarization of M1 macrophages (64, 65)

Since, both human (153, 155) and murine (163, 164) LN metastases can seed distant metastases, the abundance of heterogeneous cancer cell subclones in LNs could potentially give rise to more treatment-resistant cancer cells, such as the ferroptosis-resistant clones (62) or immune-resistant clones (57, 59), which spread systemically and generate secondary metastases