However, absorption through the gastrointestinal tract remains a significant limitation
Alla, M
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Hypomorph mutations or knockdown of many cohesin genes (SMC1, SMC3, RAD21/SCC1, STAG2) are synthetic lethal with PARPi olaparib which are attributed to the overlapping role of cohesin and PARP1/2 in preventing replication fork collapse (Liu et al, 2018
These findings underscore the potential of PDHA1 inhibition to counteract Enz resistance by reactivating cuproptosis, offering a promising therapeutic approach for treating refractory prostate cancer