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The anti-inflammatory effect of curcumin is most likely associated with its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS) (164)

Patch clamp electrophysiology Membrane currents were recorded in the whole-cell configuration under conditions of voltage clamp in which cells were bathed in SES 33,34

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Details regarding parameter values, including inter-individual, inter-occasion and residual variability, are provided in Table 1 of the Electronic Supplementary Material (ESM)

In the UK, the regulatory pathway for new medicines requires submission of a Marketing Authorisation Application (MAA) to the MHRA