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While Dihexa-specific desensitization kinetics havent been comprehensively characterized, research on HGF and c-Met receptor signaling in other contexts indicates receptor downregulation begins within 24-48 hours of sustained agonist exposure, with maximum internalization occurring around 72 hours

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Patients who use the appetite suppression window to build sustainable dietary habits , establish regular exercise routines, and address the psychological drivers of overeating have dramatically better outcomes when medication stops or decreases

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