mounjaro/tirzepatide Switch to Tirzepatide in T2D More Effective Than Upping Dulaglutide Dose Mounjaro (tirzepatide) + GLP-1 support

New England Journal of Medicine , 389(6), 514526

Peptide therapy amplifies this process by introducing peptides that stimulate these healing pathways more effectively

Weight loss outcomes vary by agent and dose: high-dose semaglutide (2.4mg/Wegovy) has shown mean weight reductions of approximately 15% in the STEP clinical trials, while liraglutide (3mg/Saxenda) typically achieves 5-8% weight loss

If mounjaro stopped working, it may be due to a plateau rather than true resistance

It did both of these things while crossing the blood-brain barrier and maintaining a plasma half-life exceeding 6 hours, which means sustained brain exposure from a single administration