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There is no evidence to support using allulose as a substitute for pharmaceutical GLP-1 receptor agonists in patients for whom these medications are indicated

Researchers discerned no correlation between the incidence of muscle cramps and factors such as edema, ascites, diuretic use, alcohol consumption, but have identified the presence of liver cirrhosis, higher total serum bilirubin levels, and lower serum albumin levels as risk factors for development of muscle cramps (25, 28)

Side effects are rare and mild but may include slight tenderness, redness, or bruising at the injection site, which typically fades within a few hours

Metformin, a widely-used medication, addresses this issue by improving insulin sensitivity, reducing excess testosterone, and helping restore hormonal balance

None are randomized controlled trials