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It was found that GLP-1 when bound to GLP-1R (Figure 1), can increase the concentration of cAMP by activating adenylate cyclase (AC) and stimulating the conversion of ATP to cyclic adenosine monophosphate (cAMP)

The MVK gene is located on chromosome 12q24.11 and is composed of 12 exons that generate three alternatively spliced mRNAs that collectively encode two distinct protein isoforms

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In an HG-induced HK-2 model, dual-specificity protein phosphatase 1 (DUSP1) was found to attenuate renal tubular mitochondrial dysfunction by restoring Parkin-mediated mitophagy [122]

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