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3.2.2 Experimental studies and mechanisms of PD Pathological accumulation of metal ions or a rapid increase in monoamine oxidase B (MAO-B) activity can induce endogenous dopamine (DA) oxidation, leading to -synuclein aggregation, mitochondrial dysfunction, and other factors contributing to the heightened incidence of PD

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The SURPASS head-to-head trial (SURMOUNT-5) showed tirzepatide 10mg and 15mg produced significantly greater weight loss than semaglutide 2.4mg, which is the maximum approved semaglutide dose