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As of March 31, 2024, the FDA received 442 adverse event reports related to compounded semaglutide, including 319 serious cases, 99 hospitalizations, and 7 deaths

93 In the randomized clinical trial STEP-HFpEF, patients who did not have T2D were assigned to either semaglutide 2.4 mg once weekly or placebo and followed for 52 weeks

Receptor GLP-1R it is expressed in many types of tissues: beta cells of the islets of Langerhans of the pancreas, hypothalamic neurons (arcuate nucleus, nucleus of the solitary tract), cardiomyocytes, vascular endothelial cells and hepatocytes