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But when Tylenol doses are high, or when glutathione reserves are depleted (from alcohol, poor diet, pregnancy, or chronic illness), the livers defense system collapses

It activates protein phosphatase 2A, which removes the regulating phosphate group from the liver bifunctional enzyme, the inactivating phosphate from pyruvate kinase, and an inactivating phosphate group from a transcription factor, ChREBP (Carbohydrate Response Element Binding Protein) that activates transcription of genes for fatty acid synthesis in the liver

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These receptors influence AH dynamics, IOP, retinal function, blood flow, and neuroprotection (90)