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Unscheduled lab visits should be triggered by: persistent severe nausea or vomiting, unusual fatigue, significant swelling in lower extremities, vision changes, or abdominal pain not consistent with typical GI side effects

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Semaglutide, tirzepatide, and retatrutide representing mono-agonist, dual-agonist, and triple-agonist approaches respectively have been studied extensively in clinical trials focused on metabolic function and body composition

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