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The GH/IGF-1 system regulates glomerular hemodynamics, renal gluconeogenesis, tubular sodium and water, phosphate, and calcium handling, as well as renal synthesis of 1,25 (OH) 2 vitamin D 3 and the antiaging hormone Klotho

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This tissue expansion process continues in phase 2, characterized by hormone responsiveness ( ESR1 , PGR ) and increased energy consumption (CKB , SCGB1D2 , HGD , IDO1 , ATP1A1 , PSAT1) [11] (Fig

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