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Description

Inpatient populations with severe AUD often present with secondary depression, characterized by melancholic features such as diurnal mood variation and non-reactive affect, which resolve partially with sustained abstinence (McHugh and Weiss 2019)

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Pharmacological studies have demonstrated that OGA inhibitors can effectively elevate O-GlcNAcylation, decrease amyloid aggregates formation, and reduce neuronal death in animal models of AD and PD [178, 180, 183, 184]

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