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Aggregated peptides lose biological activity and can trigger immune responses if administered

Compounded semaglutide from bulk API has no pediatric safety data, no pediatric dosing validation, and no pediatric pharmacokinetic studies

We wanted to look at this systematically in part to address the Catch-22 of third-party payers declining to cover these anti-obesity drugs because people quit them at a higher rate, when in truth some people stop the medications because coverage was terminated by the insurance company or the patient failed pre-authorization or they simply can't afford the out- of-pocket cost. Data is also important for clinicians and patients, he adds

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