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These are earlier in development but offer tantalizing glimpses of what may be possible

10.1016/j.foodres.2021.110631 130 WestphalD.KluckR

The navigation guide systematic review methodology: A rigorous and transparent method for translating environmental health science into better health outcomes

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

The trials were too short to assess any impact on coronary heart disease or mortality