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While hyperinflammation due to proinflammatory cytokine overproduction has been frequently documented, it is recently recognized that the immune response is markedly suppressed in some cases by the expansion and activity of MDSCs (myeloid-derived suppressor cells) and FoxP3 + Tregs (regulatory T cells)

However, clinical studies with liraglutide have shown that this effect is generally modest and does not significantly impact the efficacy of most medications tested, including paracetamol and oral contraceptives