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Even if the J-curve benefit were real, its absolute magnitude would likely be smaller today than in the studies that generated the original data (Blakely & Wilson, 2014)

In a letter dated Feb

Symptoms can vary between individuals

Delayed gastric emptying from GLP-1 drugs could theoretically alter the timing of oral absorption for any substance

The changes are relevant for Highmark business in Pennsylvania, West Virginia, Delaware and New York: The changes include the introduction of Step Therapy (requiring members to try preferred medications first) and Quantity Limits (restricting the amount of certain medications dispensed)