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Designed in convenient capsule form, they ensure ease of use and precise dosing

RSL3, on the other hand, forms a covalent bond with GPX4, deactivating it and disturbing the cellular redox equilibrium, elevating lipid peroxidation and inducing ferroptosis [39]

147 Overexpression of miR-144-3p could downregulate the GSH/GSSG ratio, increase the levels of ROS, Fe 2+ , and ACSL4, promote ferroptosis and thus reduce the metastasis of osteosarcoma cells, while high expression of ZIB1 plays the opposite role, 147 indicating that miR-144-3p and its downstream ZIB1 are involved in the development and metastasis of osteosarcoma mainly by interfering with iron metabolism and redox homeostasis

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H 2 O 2 can be eliminated by CAT, various peroxidases, and AsA and GSH, which help maintain ROS homeostasis (Suzuki et al