still losing weight after stopping semaglutide loss maintenance discontinuing GLP-1 : r/Zepbound People who stop weight loss

On-treatment gain is possible

however, most available data remain observational and associative

Some experts see a place for pill formulations of GLP-1s as maintenance treatment for patients to switch to once theyve reached a target weight or blood sugar level on injectable versions.

GLP-1R regulates brain glucose metabolism The most prominent physiological effect of GLP-1 and GLP-1R is the regulation of insulin secretion in the pancreas to maintain postprandial glucose homeostasis, whereas outside the pancreas, GLP-1 and GLP-1R also regulate feeding and metabolism through the nervous system

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