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These reactions were observed in clinical trials: Abdominal distension Abdominal pain Acute gallbladder disease Acute kidney injury Acute pancreatitis Allergic reactions Constipation Diarrhea Dizziness Dyspepsia (indigestion) Eructation (burping) Fatigue Flatulence Gastroenteritis Gastroesophageal reflux disease Headache Hypoglycemia (in diabetic patients) Nasopharyngitis (cold) Nausea Thyroid C-cell tumors Vomiting Studies, consumer reports and lawsuits have highlighted other side effects of semaglutide medications

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28, 2025, the FDA also approved Ozempic to reduce the risk of worsening kidney disease in people with Type 2 diabetes and chronic kidney disease