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In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)

Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer

T., Akmakjian, A., & Abdou, A

The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate