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The liver is the main site of IGF-I production and is regulated by GH

FOXO4-DRI counteracts senescence and features of frailty in fast aging Xpd TTD/TTD mice TTD/TTD We next wondered whether FOXO4-DRI could influence the healthspan of mice in which senescence and the concomitant loss of tissue homeostasis were not actively induced, but were allowed to develop spontaneously as a consequence of aging

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The significant reduction in oxygen uptake and the tendency to achieve lower blood lactate concentrations at the final ergometric load (VO2peak) during fasting observed in our study are also likely related to lower maximum power output and shorter exercise test duration