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Loss of PRDX6 reduces GPX4 protein levels and sensitizes cells to ferroptosis

doi: 10.1124/dmd.119.089557

The stomachs acids can break it down before it reaches your bloodstream

Then, the rate-limiting enzyme in arginine synthesis, argininosuccinate synthetase 1 (ASS1), catalyzes the conversion of citrulline and aspartate into argininosuccinate, which is then cleaved into arginine and fumarate by argininosuccinate lyase (ASL) (Figure 1)

This unbalanced regulation of the glutathione oxidation/reduction cycle indicates the existence of an alternative pathway to regenerate GSH from GSSG to maintain a stable GSSG/GSH ratio