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The side effects are generally the same whether you take Ozempic for type 2 diabetes or weight loss

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it upregulates the expression of tight junction proteins (e.g., ZO-1 and occludin) in colon tissue, repairs the intestinal epithelial barrier, reduces serum FD4 (fluorescein isothiocyanatedextran) levels, decreases intestinal permeability, prevents bacterial and metabolite translocation, and lowers serum LPS levels

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Neuroscientists describe this as a dampening of dopamine signalling across reward pathways