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Avoid areas close to the knee or hip, as they might be more sensitive
Muscle tissue burns more calories at rest than fat tissue, so preserving muscle during weight loss maintains metabolic rate
The motivation is gone because it no longer induces the same reward it did, which I think the only way around that, if the person really needs the medication, is to have either external ways of being motivated, such as having a trainer who goes, Get out there and do your lifting, or, enough internal sense of, I need to do this because it's good for me, not because it feels good anymore. Which is a very difficult position
If symptoms continue or worsen, seek medical care