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The hypothalamus requires adequate energy reserves to maintain the pulsatile secretion of gonadotrophin-releasing hormone (GnRH), which stimulates the pituitary gland to produce luteinising hormone (LH) and follicle-stimulating hormone (FSH)

For details see the When to Take section of the Protein Powder and Drinks Review

Answer: There is no strict upper limit, but most protocols build in breaks after 12 to 16 weeks of continuous use to limit tolerance

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