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Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy

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Peptides are fragile chains of amino acids

Minor bruising, redness, or discomfort at the injection site is possible

368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption