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It's a method that moves beyond simple observation, pushing towards a more holistic understanding of biological systems

Ethics declarations Ethical approval This study was conducted per the NIH Guidelines for the Care and Use of Laboratory animals strictly adherent to the ARRIVE guidelines and accepted by The Institutional Animal Care and Use Committee, Cairo University (CU-IACUC), Egypt (Code: CU/III/F/15/23)

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Additionally, conditions like heart failure can impair circulation, triggering similar responses

The CapnCollar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes