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Parkinsons disease (PD) PD is characterized by the accumulation of oligomeric -synuclein (-syn), and dopaminergic neuron degeneration observed in the part of substantia nigra- pars compacta (SNpc) which further prompts motor impairments [116]

1C and Supplementary Fig

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Interestingly, Fab 3F52 also blocked a short peptide agonist believed to engage primarily the transmembrane and extracellular loop region of GLP-1R, whereas functionality of an allosteric small-molecule agonist was not inhibited

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