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In addition, the fat mass and obesity-associated gene ( FTO ), a well-recognized obesity-susceptibility gene, plays a crucial role in regulating semaglutides efficacy by modulating appetite and energy metabolism

For patients on beta-blockers, the compensatory blunting of heart rate elevation may mask this signal

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Within the Hallmarks of Aging framework, their effects are most evident across metabolic, inflammatory, and mitochondrial pathways that connect cellular stress to systemic dysfunction

Data were obtained from literature mining and the rates of body weight change from the initial values were selected as the therapeutic index