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While the GLP-1s affected familiar territory, they also triggered activity in the central amygdala, a region associated with desire that is deeper in the brain than scientists previously thought GLP-1s could directly reach

For example, in conditions such as inborn errors of metabolism (e.g., medium-chain acyl-CoA dehydrogenase deficiency), accumulating acyl-CoA intermediates are converted into acylcarnitines and excreted via urine

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The discomfort is temporary, but the transformation is lasting