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These conclusions are based on a study involving 710 patients with Type 2 diabetes

NO and mitochondria Role of NO in mitochondrial biogenesis Although the underlying mechanisms are not fully understood, several studies indicate an interaction between NO and a mitochondrial biogenesis regulator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1) (Lira et al., 2010

Orlistat, which works through a different mechanism (reducing fat absorption), may be an option, though it carries its own distinct side effect profile, primarily gastrointestinal

Chemistry 287, 106821