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Additionally, musculoskeletal complaints are prevalent in the general populationparticularly among individuals with obesity, diabetes, and advancing agemaking it challenging to determine whether such symptoms are medication-related

They also reduce cardiovascular events that compete with cancerspecific risks, suggesting a dual pathway to improved survival. As for the next steps of this research, Cuomo said first is a randomized, controlled evaluation of GLP1 RAs as an adjunct to standard colon cancer therapy, stratified by body mass index (BMI) and timed relative to surgery and systemic therapy

Some considerations and risks of long-term use include metabolic effects that could be changes in insulin sensitivity and cardiovascular effects that could shift blood pressure or lipid levels in vulnerable individuals

Therapeutic targets in the Wnt signaling pathway: feasibility of targeting TNIK in colorectal cancer