Consistent with the notion that lifestyle intervention may add only modest incremental weight loss once pharmacotherapy is initiated, the SURMOUNT-3 trial showed that, after a 12-week intensive lifestyle lead-in, participants continuing lifestyle with placebo had a + 2.5% weight change by week 72, whereas those receiving tirzepatide achieved an additional 18.4%, highlighting the dominant contribution of tirzepatide to further weight reduction [15]
As peer-reviewed Phase 3 results publish, this guide is updated with the confirmed figures
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The phenomenon is called the bone fragility diabetes paradox, indicating that other factors besides BMD may affect fracture risk
