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This SRM has several limitations, including the exclusion of some available RCTs, restriction to studies conducted among patients with diabetes, and the absence of subgroup analyses for different tirzepatide doses

Indeed, in a model of graft-versus-host disease (GVHD), T-cell-depleted bone marrow transplants fed with TMAO-rich diet exhibited a significant increase in the frequency of F4/80 + CD11b + CD16/32 + inflammatory macrophages relative to the F4/80 + CD11b + whole population, worsening disease severity, and increasing mortality (80)

2017;13:e1007024