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Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited

Efflux may affect efficacy of TGR inhibitors ex vivo Compounds 7 - 9 were found to have significant NTS killing activity, but the decrease in GSH/GSSG ratio was attenuated and less adult schistosomicidal activity was observed

Adverse drug reactions

In addition to working as an electron carrier, the oxidized cyt c also serves as a scavenger of reactive oxygen species (ROS) (Wang et al., 2003), a cardiolipin peroxidase (Kagan et al., 2005), and an apoptosis activator once released to the cytosol (Ow et al., 2008)